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PUBLICATIONS

Original Articles

  1. Liu W, Cronin CG, Cao Z, Wang C, Ruan, J, Pulikkot S, Hall A, Sun H, Groisman A, Chen Y, Vella AT, Hu L, Liang BT*, Fan Z*. Nexinhib20 inhibits neutrophil adhesion and β2 integrin activation by antagonizing Rac-1-guanosine 5’-triphosphate interaction. The Journal of Immunology. 2022; 209(8):1574-1585. doi: 10.4049/jimmunol.2101112. (*corresponding authors)

  2. Liu W, Hsu AY, Wang Y, Lin T, Sun H, Pachter JS, Groisman A, Imperioli M, Yungher FW, Hu L, Wang P, Deng Q, Fan Z*. Mitofusin-2 regulates the adhesion of neutrophil-like HL60 cells through the maturation of β2 integrin activation. Journal of Leukocyte Biology. 2021; online ahead of print, https://doi.org/10.1002/JLB.1A0720-471R. (*corresponding author)

  3. Fan Z, Pitmon E, Wen L, Miller J, Ehinger E, Herro R, Liu W, Chen J, Mikulski Z, Conrad DJ, Marki A, Orecchioni M, Kumari P, Zhu YP, Marcovecchio PM, Hedrick CC, Hodges CA, Rathinam VA, Wang K, Ley K. Bone marrow transplantation rescues monocyte recruitment defect and improves cystic fibrosis in mice. The Journal of Immunology. 2022; 208(3):745-752.

  4. Fan Z, Mikulski Z, McArdle S, Sundd P, Ley K. Super-STORM: using molecular structure modeling to sharp images of single molecule localization microscopy. STARprotocol. 2020; 1(1): 100012. (*corresponding authors).

  5. Sun H*, Fan Z*, Gingras AR, Lopez-Ramirez MA, Ginsberg MH, Ley K. A flexible kink in the transmembrane domain impairs β2 integrin extension and cell arrest from rolling. Journal of Leukocyte Biology. 2020; 107(2): 175-183. (*co-first authors)

  6. Fan Z, Kiosses WB, Sun H, Orecchioni M, Ghosheh Y, Zajonc DM, M. Arnaout A, Gutierrez E, Groisman A, Ginsberg MH, Ley K. High affinity-bent β2 integrin molecules in arresting neutrophils face each other: role of binding to ICAMs in cis. Cell Reports. 2019; 26(1): 119-130.

  7. Fan Z, McArdle S, Marki A, Mikulski Z, Gutierrez E, Engelhardt B, Deutsch U, Ginsberg MH, Groisman A, Ley K. Neutrophil recruitment limited by high affinity bent β2 integrin binding ligand in cis. Nature Communications. 2016; 7: 12658.

  8. Fan ZC, Yan J, Liu GD, Tan XY, Weng XF, Wu WZ, Zhou J, Wei XB. Real-Time Monitoring of Rare Circulating Hepatocellular Carcinoma Cells in an Orthotopic Model by In Vivo Flow Cytometry Assesses Resection on Metastasis. Cancer Research. 2012; 72(10): 2683-2691.

  9. Fan Z, Cui X, Wei D, Liu W, Li B, He H, Ye H, Zhu N, Wei XB. eEF1A1 binds and enriches protoporphyrin IX in cancer cells in 5-aminolevulinic acid based photodynamic therapy. Scientific Reports. 2016; 6:25353.

  10. Wang L*, Fan Z*, Zhang J, Changyi Y, Huang C, Gu Y, Xu Z, Tang Z, Lu W, Wei X, Li C. Evaluating Tumor Metastatic Potential by Imaging Intratumoral Acidosis via pH-Activatable Near-infrared Fluorescence Probe. International Journal of Cancer. 2015; 136(4): E107-E116. (*co-first authors)

  11. Hu L*, Fan Z*, Du H, Ni R, Zhang S, Yin K, Ye J, Zhang Y, Wei X, Zhang X, Gross PL, Kunapuli SP, Ding Z. BF061, a novel antiplatelet and antithrombotic agent targeting P2Y12 receptor and phosphodiesterase. Thrombosis and Haemostasis. 2011; 106(6): 1203-1214. (*co-first authors)

  12. Lin W*, Fan Z*, Suo Y, Deng Y, Zhang M, Wang JY, Wei X, Chu Y. The bullseye synapse formed between CD4+ T cell and staphylococcal enterotoxin B-pulsed dendritic cell is a suppressive synapse in T-cell response. Immunology & Cell Biology. 2015; 93(1):99-110. (*co-first authors)

  13. Yan J*, Fan Z*, Wu X, Xu M, Jiang J, Tan C, Wu W, Wei X, Zhou J. Circulating tumor cells are correlated with disease progression and treatment response in an orthotopic hepatocellular carcinoma model. Cytometry Part A. 2015; 87(11):1020-1028. (*co-first authors)

  14. Li Y*, Fan Z*, Guo J, Liu G, Tan X, Wang C, Gu Z, Wei X. Circulation times of hepatocellular carcinoma cells by in vivo flow cytometry. Chinese Optics Letters. 2010; 8(10): 953-956. (*co-first authors)

  15. Jiang X*, Fan Z*, Yu Y, Shao C, Suo Y, Wei X, Zhou Y. Toluidine blue O and porphyrin-mediated photodynamic therapy on three main pathogenic bacteria of periodontitis using portable LED phototherapy. Journal of Innovative Optical Health Sciences. 2015; 8(4): 1550017. (*co-first authors)

  16. Orecchioni M, Kobiyama K, Winkels H, Ghosheh Y, McArdle S, Mikulski Z, Kiosses WB, Fan Z, Wen L, Jung Y, Roy P, Ali AJ, Miyamoto Y, Mangan M, Makings J, Wang Z, Denn A, Vallejo J, Owens M, Durant CP, Braumann S, Mader N, Li L, Matsunami H, Eckmann L, Latz E, Wang Z, Hazen SL, Ley K. Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production. Science. 2022; 375(6577): 214-221.

  17. Chen Y, Fu W, Zheng Y, Yang J, Liu Y, Qi Z, Wu M, Fan Z, Yin K, Chen Y, Gao W, Ding Z, Dong J, Li Q, Zhang S, Hu L. Galectin 3 enhances human platelet aggregation and thrombosis via Dectin-1 activation. European Heart Journal. 2022, 43(37):3556-3574. doi: 10.1093/eurheartj/ehac034.

  18. Lagarrigue F, Tan B, Du Q, Fan Z, Lopez-Ramirez MA, Gingras AR, Wang H, Qi W, Sun H. Direct Binding of Rap1 to Talin1 and to MRL Proteins Promotes Integrin Activation in CD4+ T Cells. The Journal of Immunology. 2022, 208(6):1378-1388. doi: 10.4049/jimmunol.2100843.

  19. Fujii Y, Monteiro N, Sah SK, Javaheri H, Ueki Y, Fan Z, Reichenberger E, Chen IP. Tlr2/4-mediated Hyperinflammation Promotes Cherubism-like Jawbone Expansion in Sh3bp2 (P416R) Knockin Mice. JBMR Plus. 2021; 6(1):e10562. https://doi.org/10.1002/jbm4.10562.

  20. Sun H, Lagarrigue F, Wang H, Fan Z, Lopez-Ramirez MA, Chang JT, Ginsberg MH. Distinct integrin activation pathways for effector and regulatory T cell trafficking and function. Journal of Experimental Medicine. 2021; 218 (2): e20201524.

  21. Marki A, Buscher K, Lorenzini C, Meyer M, Saigusa R, Fan Z, Yeh YT, Hartmann N, Dan JM, Kiosses WB, Golden GJ, Ganesan R, Winkels H, Orecchioni M, McArdle S, Mikulski Z, Altman Y, Bui J, Kronenberg M, Chien S, Esko JD, Nizet V, Smalley D, Roth J, Ley K. Elongated neutrophil-derived structures are blood-borne microparticles formed by rolling neutrophils during sepsis. Journal of Experimental Medicine. 2021;218(3):e20200551.

  22. Wen L, Marki A, Roy P, McArdle S, Sun H, Fan Z, Gingras A, Ginsberg M, Ley K. Kindlin-3 recruitment to the plasma membrane precedes high affinity β2 integrin and neutrophil arrest from rolling. Blood. 2021;137(1):29-38.

  23. Zhang S, Liu Y, Wang X, Yang L, Li H, Wang Y, Liu M, Zhao X, Xie Y, Yang Y, Zhang S, Fan Z, Dong J, Yuan Z, Ding Z, Zhang Y, Hu L. SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19. Journal of Hematology & Oncology. 2020; 13: 120.

  24. Wolf D, Anto-Michel N, Blankenbach H, Wiedemann A, Buscher K, Hohmann JD, Lim B, Bäuml M, Marki A, Mauler M, Duerschmied D, Fan Z, Winkels H, Sidler D, Diehl P, Zajonc D, Hilgendorf I, Stachon P, Marchini T, Willecke F, Schell M, Sommer B, von zur Muhlen C, Reinöhl J, Gerhardt T, Plow E, Yakubenko V, Libby P, Bode C, Ley K, Peter K, Zirlik A. A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defense. Nature Communications. 2018; 9 (1): 525.

  25. Sun H, Lagarrigue F, Gingras A, Fan Z, Ley K, Ginsberg M. Transmission of integrin β7 transmembrane domain topology enables gut lymphoid tissue development. Journal of Cell Biology. 2018; 217(4):1453-1465.

  26. Abadier M, Pramod AB, McArdle S, Fan Z, Gutierrez E, Groisman A, Ley K. Effector and regulatory T cells roll at high shear stress by inducible tether and sling formation. Cell Reports. 2017; 21(13):3885-3899.

  27. Lin W, Buscher K, Wang B, Fan Z, Song N, Li P, Yue Y, Li B, Li C, Bi H. Soluble CD83 alleviates experimental autoimmune uveitis by inhibiting F-actin-dependent calcium-release in dendritic cells. Frontiers in Immunology. 2018; 9: 1567.

  28. Liao Y, Cheng Y, Liu C, Song J, He F, Shen Y, Chen D, Xu Z, Fan Z, Wei X, Sugioka K, Midorikawa K. Direct laser writing of sub-50 nm nanofluidic channels buried in glass for three-dimensional micro-nanofluidic integration. Lab on a Chip. 2013; 13(8): 1626-31.

  29. Ding Y, Wang J, Fan Z, Wei D, Shi R, Luo Q, Zhu D, Wei X. Signal and depth enhancement for in vivo flow cytometer measurement of ear skin by optical clearing agents. Biomedical Optics Express. 2013; 4(11): 2518-26.

  30. Suo Y, Xie C, Zhu X, Fan Z, Yang Z, He H, Wei X. Proportion of circulating tumor cell clusters increases during cancer metastasis. Cytometry Part A. 2017; 91 (3): 250-253.

  31. Li Y, Guo J, Wang C, Fan Z, Liu G, Wang C, Gu Z, Damm D, Mosig, A, Wei X. Circulation times of prostate cancer and hepatocellular carcinoma cells by in vivo flow cytometry. Cytometry Part A. 2011; 79(10): 848-854.

  32. Lin W, Suo Y, Deng Y, Fan Z, Zheng Y, Wei X, Chu Y. Morphological change of CD4+ T cell during contact with DC modulates T-cell activation by accumulation of F-actin in the immunology synapse. BMC Immunology. 2015;16:49.

  33. Guo J, Fan Z, Gu Z, Wei X. Studying the role of macrophages in circulating prostate cancer cells by in vivo flow cytometry. Journal of Innovative Optical Health Sciences. 2012; 5(4): 1250027.

  34. Suo Y, Lin W, Deng Y, Fan Z, Qin L, Jiang G, Chu Y, Wei X. ICAM-1 depletion in the center of immunological synapses is important for calcium releasing in T-cells. Journal of Innovative Optical Health Sciences, 2018; 11(2): 1750015.

Reviews and Editorals

  1. Fan Z*, Sun H*. Editorial: Adhesion molecules and autoimmune diseases. Frontiers in Immunology. 2022; 13: 1009708. (*corresponding authors)

  2. Cao Z, Zhao M, Sun H, Hu L, Chen Y, Fan Z*. Roles of mitochondria in neutrophils. Frontiers in Immunology. 2022; 13: 934444. (*corresponding author)

  3. Pulikkot S, Hu L, Chen Y, Sun H, Fan Z*. Integrin Regulators in Neutrophils. Cells. 2022; 11(13): 2025. (*corresponding author)

  4. Wu Y, Fan Z*. Peripheral blood RNAseq links neutrophilic inflammation to clinical glioma metastasis. BMC Medicine. 2021; 19: 296. (*corresponding author)

  5. Sun H, Hu L, Fan Z*. β2 integrin activation and signaling transduction in leukocyte recruitment. American Journal of Physiology-Cell Physiology. 2021; 321(2):C308-C316. (*corresponding author)

  6. Sun H*, Huo Y, Fan Z*. Editorial: Imaging and Mechanism of Leukocyte Recruitment and Function in Inflammation and Infections. Frontiers in Cell and Developmental Biology. 2021; 9: 690003. (*corresponding authors)

  7. Sun H, Zhi K, Hu L, Fan Z*. The Activation and Regulation of β2 Integrins in Phagocytes. Frontiers in Immunology. 2021; 12: 978. (*corresponding author)

  8. Cai C, Sun H, Hu L, Fan Z*. Visualization of integrin molecules by fluorescence imaging and techniques. Biocell. 2021, 45(2): 229-257. (*corresponding author)

  9. Fan Z, Ley K. Developing Neutrophils Must Eat… Themselves! Immunity. 2017; 47 (3): 393-395

  10. Fan Z, Ley K. Leukocyte Adhesion Deficiency IV: Monocyte Integrin Activation Deficiency in Cystic Fibrosis. American Journal of Respiratory and Critical Care Medicine. 2016; 193(10):1075-1077.

  11. Fan Z, Ley K. Leukocyte arrest: Biomechanics and molecular mechanisms of β2 integrin activation. Biorheology. 2015; 52(5-6):353-77.

  12. Fan Z, Wei X. In vivo flow cytometry: A powerful optical technology to detect circulating tumor cells and diagnose cancer metastasis in vivo. Photonics & Lasers in Medicine. 2013; 2(1): 27-35.

  13. Wen L, Fan Z, Mikulski Z, Ley, K. Imaging of the immune system - towards a subcellular and molecular understanding. Journal of Cell Science. 2020; 133, jcs234922.

Book Chapters

  1. Ley K, Fan Z. Leukocyte Adhesion: Fundamental Mechanisms. Handbook of Inflammation. 2018.

  2. Wei XB, Fan ZC, Wei D, Liu R, Suo Y, Weng XF. In Vivo Flow Cytometry Combined with Confocal Microscopy to Study Cancer Metastasis. Handbook of Photonics for Biomedical Engineering. 2015.

Pubmed full publications: https://www.ncbi.nlm.nih.gov/myncbi/1FAsBeTqGbVAG/bibliography/public/

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